Semisynthetic penicillins (ampicillin, nafcillin, oxacillin)Ĭlassification of Causes of AKI and Creatinine Clearance.Chinese herbs – Stephania tetrandra, Magnolia officinalis.Fluid overload and therapies to treat volume overload increase the risk of AKI and affect Creatinine Clearance.High-volume resuscitation with crystalloids has a higher risk of AKI than balanced salt solutions because of the harmful effects of chloride loading.Choice of fluid for resuscitation may be a risk factor for AKI because hydroxyethyl starch increases the AKI risk compared with crystalloids.Sepsis is a common predisposing factor to AKI, and the development of AKI further increases the risk of mortality.Acute kidney injury is common after cardiac surgery and is less common in the non-cardiac surgery population.Antimicrobials, NSAIDs, and proton pump inhibitors are common medications administered in this population.Moreover, hospitalised patients, especially critically ill patients, exposed to several nephrotoxins and contrast exposure.In addition to the proteinuria with a GFR more significant than 60 mL/ minute/1.73 m2 or an elevated urinary albumin/creatinine.Comorbid conditions including CKD, diabetes, hypertension, coronary artery disease, heart failure, liver disease, and chronic obstructive pulmonary disease are risk factors for AKI.All this compared to those whose serum creatinine levels increased after surgery.Ĭomorbid Conditions and Creatinine Clearance.Finally, the patients with decreases in serum creatinine levels from baseline immediately after surgery were less likely to develop AKI.The strongest predictors of postoperative AKI among clinical risk scores are baseline kidney function and CKD status according to the Creatinine Clearance.In addition, numerous studies derived clinical risk scores of predictors of AKI after cardiac surgery.Severe AKI requiring RRT occurs in an estimated 1–2% of these patients.The estimated incidence of AKI in cardiac surgery patients is 11–30%.Furthermore, the overall utility of these definitions and staging systems in the clinical assessment and management of patients with AKI remains to be validated.Moreover, these definitions based exclusively upon the serum Creatinine Clearance and urine output and are used primarily to identify patients with AKI in epidemiologic and outcome studies.Several consensus definitions of AKI developed to provide a uniform definition of AKI.Additionally, associated with increased morbidity and mortality.The term AKI has largely replaced acute renal failure (ARF), reflecting the recognition that smaller decrements in kidney function that do not result in overt organ failure are of substantial clinical relevance.This is resulting in the retention of urea and other nitrogenous waste products and the dysregulation of extracellular volume and electrolytes.Acute kidney injury (AKI) refers to an abrupt decrease in kidney function.Drug Dosing According to Creatinine Clearance Calculation.Definition of Creatinine Clearance & formula.Medications affected the AKI and Creatinine Clearance.Fluid resuscitation in AKI and Creatinine Clearance.Serum Creatinine Level and Creatinine Clearance.Diagnosis of AKI and Creatinine Clearance.Classification of Causes of AKI and Creatinine Clearance.
Comorbid Conditions and Creatinine Clearance.